4-quinolone antibiotics: Positive genotoxic screening tests despite an apparent lack of mutation induction

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Bibtex

@article{7376ff6bf3dd4a808cf6d7c0c956f196,
title = "4-quinolone antibiotics: Positive genotoxic screening tests despite an apparent lack of mutation induction",
abstract = "The effects of different 4-quinolone antibiotic derivatives (4-Qs) in a number of short-term tests commonly employed for the evaluation of genetic toxicity were studied. Incorporation of [3H]thymidine into mitogen-stimulated peripheral blood lymphocytes was strongly enhanced at a low concentration (1.56 μg/ml) for most of the tested 4-Qs, whereas DNA strand breakage in lymphoblastoid cells was evident only for ciprofloxacin (10 μg/ml and upwards), ofloxacin (80 μg/ml) and norfloxacin (160 μg/ml). Ciphrofloxacin induced a significant amount of unscheduled DNA synthesis, but was found to be negative in a shuttle vector plasmid mutation test. Ciprofloxacin (80 μg/ml) did not inhibit enzymes involved in the early steps of pyrimidine biosynthesis. Cell growth was slightly depressed at a concentration of 20 μg/ml, becoming marked at 80 μg/ml. In conculsion, this study seeks to contribute to an improved evaluation of genotoxic screening test data, by focuding attention on the conflicting effects imposed by the 4-Qs on a battery of such tests.",
keywords = "4-Quinolones, DNA repair, DNA synthesis, Gene mutation, Genetic toxicity",
author = "Anders Bredberg and Marta Brant and Kristian Riesbeck and Yannick Azou and Arne Forsgren",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0027-5107(89)90117-6",
language = "English",
volume = "211",
pages = "171--180",
journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",
issn = "1879-2871",
publisher = "Elsevier",
number = "1",

}