5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Abstract
5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.
Detaljer
Författare | |
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Enheter & grupper | |
Forskningsområden | Ämnesklassifikation (UKÄ) – OBLIGATORISK
Nyckelord |
Originalspråk | engelska |
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Sidor (från-till) | 1377-1382 |
Tidskrift | Neuropharmacology |
Volym | 26 |
Utgåva nummer | 9 |
Status | Published - 1987 |
Publikationskategori | Forskning |
Peer review utförd | Ja |