A 59-kd renal antigen as a new target for rapidly progressive glomerulonephritis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.

Detaljer

Författare
  • Vincent Audard
  • Thomas Hellmark
  • Khalil El Karoui
  • Laure Helene Noel
  • Agathe Pardon
  • Dominique Desvaux
  • Guy Touchard
  • Philippe Remy
  • Philippe Lang
  • Djillali Sahali
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Urologi och njurmedicin

Nyckelord

Originalspråkengelska
Sidor (från-till)710-716
TidskriftAmerican Journal of Kidney Diseases
Volym49
Utgåva nummer5
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa