A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis

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Bibtex

@article{42b889de6a9b4567b72c253d20080bcf,
title = "A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis",
abstract = "Objective: Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-mediated COL1 biomarker, C1M, was associated with cardiovascular events, cardiovascular mortality and all-cause mortality in a large prospective cohort of patients with known atherosclerosis. Methods: Serum from 787 patients who underwent a carotid endarterectomy was included. Circulating levels of C1M were measured in serum. A total of 473 patients were followed for 6 years after surgery. Associations between C1M and incidence of cardiovascular events, cardiovascular mortality and all-cause mortality were assessed by Kaplan–Meier curves and Cox regression analysis. Results: A total of 101 (21.4{\%}) patients suffered from nonfatal cardiovascular events during the follow-up period, and 64 (13.5{\%}) patients died. Of these, 39 (60.9{\%}) died from cardiovascular diseases. Patients with C1M levels above the median were significantly associated with cardiovascular events, cardiovascular mortality and all-cause mortality (P < 0.001, P = 0.004 and P < 0.001, respectively). C1M was included in the final model for prediction of cardiovascular events (HR 2.15, 95{\%} CI 1.40–3.32, P = 0.001), cardiovascular mortality (HR 2.20, 95{\%} CI 1.07–4.51, P = 0.031) and all-cause mortality (HR 2.98 95{\%} CI 1.67–5.33, P = < 0.001). Conclusions: In patients with atherosclerotic carotid lesions, high levels of C1M predicted cardiovascular events, cardiovascular mortality and all-cause mortality. These findings emphasize the importance of remodelling mechanisms in atherosclerosis that are now becoming more and more explored.",
keywords = "atherosclerosis, biomarkers, collagen, extracellular matrix, inflammation",
author = "{Holm Nielsen}, S. and C. Tengryd and A. Edsfeldt and S. Brix and F. Genovese and E. Bengtsson and M. Karsdal and Leeming, {D. J.} and J. Nilsson and I. Goncalves",
year = "2019",
month = "1",
doi = "10.1111/joim.12819",
language = "English",
volume = "285",
pages = "118--123",
journal = "Journal of Internal Medicine",
issn = "1365-2796",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "1",

}