A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to treatment and prognosis. It is also essential for research. We propose a classification that accommodates both a current understanding of causation (level 1) and clinical association in cases for whom cause of disease is unclear (level 2). We tested the classification in a pediatric disease registry of HUS. The revised classification is a stimulus to comprehensive investigation of all cases of HUS and TTP and is expected to increase the proportion of cases in whom a level 1 etiological diagnosis is confirmed.

Detaljer

Författare
  • N. Besbas
  • Diana Karpman
  • D. Landau
  • C. Loirat
  • W. Proesmans
  • G. Remuzzi
  • G. Rizzoni
  • C. M. Taylor
  • N. Van de Kar
  • L. B. Zimmerhackl
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Urologi och njurmedicin

Nyckelord

Originalspråkengelska
Sidor (från-till)423-431
TidskriftKidney International
Volym70
Utgivningsnummer3
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördJa