A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders

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A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. / Besbas, N.; Karpman, Diana; Landau, D.; Loirat, C.; Proesmans, W.; Remuzzi, G.; Rizzoni, G.; Taylor, C. M.; Van de Kar, N.; Zimmerhackl, L. B.

I: Kidney International, Vol. 70, Nr. 3, 2006, s. 423-431.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Harvard

Besbas, N, Karpman, D, Landau, D, Loirat, C, Proesmans, W, Remuzzi, G, Rizzoni, G, Taylor, CM, Van de Kar, N & Zimmerhackl, LB 2006, 'A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders', Kidney International, vol. 70, nr. 3, s. 423-431. https://doi.org/10.1038/sj.ki.5001581

APA

CBE

Besbas N, Karpman D, Landau D, Loirat C, Proesmans W, Remuzzi G, Rizzoni G, Taylor CM, Van de Kar N, Zimmerhackl LB. 2006. A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. Kidney International. 70(3):423-431. https://doi.org/10.1038/sj.ki.5001581

MLA

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Author

Besbas, N. ; Karpman, Diana ; Landau, D. ; Loirat, C. ; Proesmans, W. ; Remuzzi, G. ; Rizzoni, G. ; Taylor, C. M. ; Van de Kar, N. ; Zimmerhackl, L. B. / A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. I: Kidney International. 2006 ; Vol. 70, Nr. 3. s. 423-431.

RIS

TY - JOUR

T1 - A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders

AU - Besbas, N.

AU - Karpman, Diana

AU - Landau, D.

AU - Loirat, C.

AU - Proesmans, W.

AU - Remuzzi, G.

AU - Rizzoni, G.

AU - Taylor, C. M.

AU - Van de Kar, N.

AU - Zimmerhackl, L. B.

PY - 2006

Y1 - 2006

N2 - The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to treatment and prognosis. It is also essential for research. We propose a classification that accommodates both a current understanding of causation (level 1) and clinical association in cases for whom cause of disease is unclear (level 2). We tested the classification in a pediatric disease registry of HUS. The revised classification is a stimulus to comprehensive investigation of all cases of HUS and TTP and is expected to increase the proportion of cases in whom a level 1 etiological diagnosis is confirmed.

AB - The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to treatment and prognosis. It is also essential for research. We propose a classification that accommodates both a current understanding of causation (level 1) and clinical association in cases for whom cause of disease is unclear (level 2). We tested the classification in a pediatric disease registry of HUS. The revised classification is a stimulus to comprehensive investigation of all cases of HUS and TTP and is expected to increase the proportion of cases in whom a level 1 etiological diagnosis is confirmed.

KW - hemolytic uremic syndrome

KW - thrombotic thrombocytopenic purpura

KW - etiology

U2 - 10.1038/sj.ki.5001581

DO - 10.1038/sj.ki.5001581

M3 - Review article

VL - 70

SP - 423

EP - 431

JO - Kidney International

T2 - Kidney International

JF - Kidney International

SN - 1523-1755

IS - 3

ER -