A critical evaluation of wet biomarkers for huntington's disease: Current status and ways forward

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Manchester
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)109-135
Antal sidor27
TidskriftJournal of Huntington's disease
Volym7
Utgivningsnummer2
StatusPublished - 2018 jan 1
PublikationskategoriForskning
Peer review utfördJa