A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning

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Bibtex

@article{f1cfc3ce8a1a41b0bfa45611ab5d5511,
title = "A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning",
abstract = "Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) or phospho-mutants significantly increased cell death after hypoxia/aglycemia. Moreover, deferoxamine-induced endogenous tolerance did not involve p21(WAF1/CIP1) expression in cortical neurons. Our data suggest that balanced expression and potentially posttranslational regulation of p21(WAF1/CIP1) is required for hypoxic preconditioning. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 351-355; doi:10.1038/jcbfm.2012.213; published online 9 January 2013",
keywords = "cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)), erythropoietin, hypoxia, ischemia, HIF-1 target genes, preconditioning",
author = "Philipp Mergenthaler and Claudia Muselmann and Juliane Suenwoldt and Isaev, {Nickolay K.} and Tadeusz Wieloch and Ulrich Dirnagl and Andreas Meisel and Karsten Ruscher",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)",
year = "2013",
doi = "10.1038/jcbfm.2012.213",
language = "English",
volume = "33",
pages = "351--355",
journal = "Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism",
issn = "1559-7016",
publisher = "Nature Publishing Group",
number = "3",

}