A general formalism for metabolic control analysis

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Abstract

A general formalism for Metabolic Control Analysis is derived using general sensitivity analysis and structural information of the metabolic pathway inherent in the stoichiometry matrix. The equations derived provide a general procedure for calculating the control coefficients from the elasticity coefficients using matrix algebra, and is valid for any pathway stoichiometry. The procedure diminishes the risk of deriving erroneous relations and is, due to its generality, well suited for computer handling. The formalism is mathematically stringent and is a complement to the original theorems of Metabolic Control Analysis, which were derived using ad hoc reasoning. (C) 1997 Elsevier Science Ltd.

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Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kemiteknik
Originalspråkengelska
Sidor (från-till)2599-2606
TidskriftChemical Engineering Science
Volym52
Utgåva nummer15
StatusPublished - 1997
PublikationskategoriForskning
Peer review utfördJa