A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

Detaljer

Författare
  • Giovanni Appendino
  • Lucia Maxia
  • Marcelo Bascope
  • Peter J. Houghton
  • Gonzalo Sanchez-Duffhues
  • Eduardo Munoz
  • Olov Sterner
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Organisk kemi
Originalspråkengelska
Sidor (från-till)1101-1104
TidskriftJournal of Natural Products
Volym69
Utgivningsnummer7
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördJa