A new mouse model that spontaneously develops chronic liver inflammation and fibrosis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background. The disease is transferrable to immunodeficient recipients, while polyclonal T cells from unaffected syngeneic donors can inhibit the disease phenotype. Because of the fibrotic component, early on-set, spontaneous nature and reproducibility, this novel mouse model provides a unique tool to gain further insight into the underlying mechanisms mediating transformation of chronic inflammation into fibrosis and to evaluate intervention protocols for treating conditions of fibrotic disorders.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Copenhagen
  • Oeiras
  • Göteborgs universitet
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området
Originalspråkengelska
Artikelnummere0159850
TidskriftPLoS ONE
Volym11
Utgåva nummer7
StatusPublished - 2016 jul 1
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Julia Nilsson, 2020, Lund : Lund University, Faculty of Medicine. 81 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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Related projects

Anja Schmidt-Christensen, Julia Nilsson, Dan Holmberg & Nina Fransén Pettersson

2013/08/01 → …

Projekt: ForskningIndividuellt forskningsprojekt

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