A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

Detaljer

Författare
  • G Appendino
  • C Della Porta
  • G Conseil
  • Olov Sterner
  • E Mercalli
  • C Dumontet
  • A Di Pietro
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Organisk kemi
Originalspråkengelska
Sidor (från-till)140-142
TidskriftJournal of Natural Products
Volym66
Utgivningsnummer1
StatusPublished - 2003
PublikationskategoriForskning
Peer review utfördJa