A novel model of dormancy for bone metastatic breast cancer cells

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Mortality of patients with breast cancer is due overwhelmingly to metastatic spread of the disease. Although dissemination is an early event in breast cancer, extended periods of cancer cell dormancy can result in long latency of metastasis development. Deciphering the mechanisms underlying cancer cell dormancy and subsequent growth at the metastatic site would facilitate development of strategies to interfere with these processes. A challenge in this undertaking has been the lack of models for cancer cell dormancy. We have established novel experimental systems that model the bone microenvironment of the breast cancer metastatic niche. These systems are based on 3D cocultures of breast cancer cells with cell types predominant in bone marrow. We identified conditions in which cancer cells are dormant and conditions in which they proliferate. Dormant cancer cells were able to proliferate upon transfer into supportive microenvironment or upon manipulation of signaling pathways that control dormancy. These experimental systems will be instrumental for metastasis studies, particularly the study of cellular dormancy.

Detaljer

Författare
  • Rebecca Marlow
  • Gabriella Honeth
  • Sara Lombardi
  • Massimiliano Cariati
  • Sonya Hessey
  • Aikaterini Pipili
  • Veronica Mariotti
  • Bharath Buchupalli
  • Katie Foster
  • Dominique Bonnet
  • Agamemnon Grigoriadis
  • Pranela Rameshwar
  • Anand Purushotham
  • Andrew Tutt
  • Gabriela Dontu
Enheter & grupper
Externa organisationer
  • King's College London
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)6886-99
Antal sidor14
TidskriftCancer Research
Volym73
Utgivningsnummer23
StatusPublished - 2013 dec 1
PublikationskategoriForskning
Peer review utfördJa