A novel mutation on the transferrin gene abolishes one N-glycosylation site and alters the pattern of transferrin isoforms, mimicking that observed after excessive alcohol consumption.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In the process of obtaining a driver's license, a healthy 28year old man presented increased levels of disialo-transferrin (TF) (approx. 20%, ref. value<2) by HPLC analysis of TF isoforms (%CDT), while other markers of excessive alcohol consumption (PEth, MCV and γ-GT) were in the normal range. The objective of this study was to determine the cause of the increased %CDT levels.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
Originalspråkengelska
Sidor (från-till)511-513
TidskriftClinical Biochemistry
Volym49
Utgivningsnummer6
Tidigt onlinedatum2015 dec 4
StatusPublished - 2016
PublikationskategoriForskning
Peer review utfördJa