A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The peptide GSFSIQYTYHV derived from human semenogelin I forms a transparent hydrogel through spontaneous self-assembly in water at neutral pH. Linear rheology measurements demonstrate that the gel shows a dominating elastic response over a large frequency interval. CD, fluorescence and FTIR spectroscopy and cryo-TEM studies imply long fibrillar aggregates of extended β-sheet. Dynamic light scattering data indicate that the fibril lengths are of the order of micrometers. Time-dependent thioflavin T fluorescence shows that fibril formation by GSFSIQYTYHV is a nucleated reaction. The peptide may serve as basis for development of smart biomaterials of low immunogenicity suitable for biomedical applications, including drug delivery and wound healing.

Detaljer

Författare
  • Birgitta Frohm
  • J E DeNizio
  • D S M Lee
  • L Gentile
  • U Olsson
  • Johan Malm
  • K S Akerfeldt
  • S Linse
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Läkemedelskemi
Originalspråkengelska
Sidor (från-till)414-421
TidskriftSoft Matter
Volym11
Utgåva nummer2
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa