A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.


Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi
Sidor (från-till)137-139
TidskriftContact Dermatitis
Utgåva nummer3
StatusPublished - 2012
Peer review utfördJa