A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Adult hippocampal neurogenesis is a highly dynamic process in which new cells are born, but only some of which survive. Of late it has become clear that these surviving newborn neurons have functional roles, most notably in certain forms of memory. Conventional methods to look at adult neurogenesis are based on the quantification of the number of newly born neurons using a simple cell counting methodology. However, this type of approach fails to capture the dynamic aspects of the neurogenic process, where neural proliferation, death and differentiation take place continuously and simultaneously. In this paper, we propose a simple mathematical approach to better understand the adult neurogenic process in the hippocampus which in turn will allow for a better analysis of this process in disease states and following drug therapies.

Detaljer

Författare
  • Minee L Choi
  • Faye Begeti
  • Roger A Barker
  • Namho Kim
Enheter & grupper
Externa organisationer
  • University of Cambridge
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)517-29
Antal sidor13
TidskriftHippocampus
Volym26
Utgåva nummer4
StatusPublished - 2016 apr
PublikationskategoriForskning
Peer review utfördJa