A sol-gel integrated dual-readout microarray platform for quantification and identification of prostate-specific antigen

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceeding

Abstract

Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which enables capture and identification of prostate-specific antigen (PSA) in samples. Protein microarray technologies, which involve miniaturizing spots of capture agents (such as antibody and aptamers) on a solid surface, enable multianalyte sensing and high-throughput analysis of protein-protein and protein-ligand interactions. This technique provides high-sensitivity analysis of biomarkers, as well as molecular profiling, and is thus used in the fields of life science, medicine and proteomics [1]. In clinical application, the high sensitive biomarker analysis enables early diagnosis, and prediction of prognosis and the response to treatment [2,3].

Detaljer

Författare
  • S. W. Lee
  • J. H. Lee
  • H. G. Kwon
  • T. Laurell
  • O. C. Jeong
  • S. Kim
Enheter & grupper
Externa organisationer
  • University of Tokyo
  • Dongguk University, Seoul
  • Inje University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biokemi och molekylärbiologi
Originalspråkengelska
Titel på värdpublikationMHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
FörlagInstitute of Electrical and Electronics Engineers Inc.
Antal sidor2
Volym2018-January
ISBN (elektroniskt)9781538633144
StatusPublished - 2018 feb 28
PublikationskategoriForskning
Peer review utfördJa
Evenemang28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017 - Nagoya, Japan
Varaktighet: 2017 dec 32017 dec 6

Konferens

Konferens28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
LandJapan
OrtNagoya
Period2017/12/032017/12/06