A Swedish approach to the prevention of type 1 diabetes

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title = "A Swedish approach to the prevention of type 1 diabetes",
abstract = "Background: The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. Objectives: Ongoing prediction and prevention studies in Sk{\aa}ne, Sweden are described. Methods: During September 2000 to August 2004, 35 000 children were screened at birth for genetic type 1 diabetes risk in the Diabetes Prediction in Sk{\aa}ne Study (DiPiS). In August 2004, the screening continued within the Enviromnental Determinants of Diabetes in the Young study (TEDDY). In the clinical trial Diabetes Prevention – Immune Tolerance (DiAPREV-IT), children with multiple islet autoimmunity have been included to investigate if immune tolerance with Alum-formulated GAD65 may prevent further beta-cell loss. Results: In DiPiS and TEDDY, a large number of children are followed in order to find the factors that trigger the autoimmune process leading to type 1 diabetes. Children followed in the studies develop diabetes at an early stage of disease, with few symptoms and a low frequency of diabetes ketoacidosis. DiAPREV-IT is still blinded and results will be available in December 2016. Conclusion: Large prospective studies will be needed to understand the complex process leading to type 1 diabetes. Secondary prevention may be possible in children with islet autoimmunity, but the studies are complicated by the variability of glucose metabolism and beta-cell loss.",
keywords = "pediatric diabetes, prevention, Sweden, type 1 diabetes mellitus",
author = "{Elding Larsson}, Helena",
year = "2016",
month = "7",
day = "1",
doi = "10.1111/pedi.12325",
language = "English",
volume = "17",
pages = "73--77",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Wiley-Blackwell",
number = "S22",