A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis

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A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis. / Blomgren, KB; Sundstrom, A; Steineck, G; Genell, S; Sjostedt, S; Wiholm, BE.

I: European Journal of Clinical Pharmacology, Vol. 58, Nr. 4, 2002, s. 275-283.

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Blomgren, KB, Sundstrom, A, Steineck, G, Genell, S, Sjostedt, S & Wiholm, BE 2002, 'A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis', European Journal of Clinical Pharmacology, vol. 58, nr. 4, s. 275-283. https://doi.org/10.1007/s00228-002-0471-4

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Blomgren, KB ; Sundstrom, A ; Steineck, G ; Genell, S ; Sjostedt, S ; Wiholm, BE. / A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis. I: European Journal of Clinical Pharmacology. 2002 ; Vol. 58, Nr. 4. s. 275-283.

RIS

TY - JOUR

T1 - A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis

AU - Blomgren, KB

AU - Sundstrom, A

AU - Steineck, G

AU - Genell, S

AU - Sjostedt, S

AU - Wiholm, BE

PY - 2002

Y1 - 2002

N2 - Objective: To evaluate risk factors - notably drugs - for developing acute pancreatitis. Methods: A population-based, case-control study, encompassing 1.4 million inhabitants aged 20-85 years from four regions in Sweden between 1 January 1995 and 31 May 1998. A total of 462 cases were hospitalised in surgical departments with their first episode of acute pancreatitis without previously known biliary stone disease. From a population register, 1781 controls were randomly selected. Information was obtained from medical records and through telephone interviews. Results: Fifty-seven percent of the cases were males. An expert group found evidence for biliary stones in 50% of the cases, alcohol intake in 23%, but in 29% neither of these factors were present. In all, "other" factors, e.g. drugs, could have contributed to the development of acute pancreatitis in 52% of the cases. In a multivariate analysis, the adjusted odds ratios (ORs) for H-2 antagonists were 2.4 (95% CI 1.2-4.8) for proton pump inhibitors (PPIs), 2.1 (1.2-3.4) for non-steroidal anti-inflammatory drugs (NSAIDs), 2.3 (1.3-4.0) for those derived from acetic acid and 1.9 (1.1-3.2) antibacterials for systemic use. Significant ORs were found for a history of gastrointestinal tract disorders [1.5 (1.1-1.9)] and inflammatory bowel disease (IBD) [3.4 (1.5-7.9)]. Smoking was significantly associated with acute pancreatitis [1.7 (1.2-2.1)] and, for those smoking more than 20 cigarettes per day, the OR was 4.0 (2.27.5). Alcohol in moderate amounts did not increase the risk, but for those drinking more than 420 g alcohol per week the OR was 4.1 (2.2-7.5). Conclusion: In addition to cholelithiasis, smoking and heavy alcohol use, drugs may be an important risk factor for acute pancreatitis.

AB - Objective: To evaluate risk factors - notably drugs - for developing acute pancreatitis. Methods: A population-based, case-control study, encompassing 1.4 million inhabitants aged 20-85 years from four regions in Sweden between 1 January 1995 and 31 May 1998. A total of 462 cases were hospitalised in surgical departments with their first episode of acute pancreatitis without previously known biliary stone disease. From a population register, 1781 controls were randomly selected. Information was obtained from medical records and through telephone interviews. Results: Fifty-seven percent of the cases were males. An expert group found evidence for biliary stones in 50% of the cases, alcohol intake in 23%, but in 29% neither of these factors were present. In all, "other" factors, e.g. drugs, could have contributed to the development of acute pancreatitis in 52% of the cases. In a multivariate analysis, the adjusted odds ratios (ORs) for H-2 antagonists were 2.4 (95% CI 1.2-4.8) for proton pump inhibitors (PPIs), 2.1 (1.2-3.4) for non-steroidal anti-inflammatory drugs (NSAIDs), 2.3 (1.3-4.0) for those derived from acetic acid and 1.9 (1.1-3.2) antibacterials for systemic use. Significant ORs were found for a history of gastrointestinal tract disorders [1.5 (1.1-1.9)] and inflammatory bowel disease (IBD) [3.4 (1.5-7.9)]. Smoking was significantly associated with acute pancreatitis [1.7 (1.2-2.1)] and, for those smoking more than 20 cigarettes per day, the OR was 4.0 (2.27.5). Alcohol in moderate amounts did not increase the risk, but for those drinking more than 420 g alcohol per week the OR was 4.1 (2.2-7.5). Conclusion: In addition to cholelithiasis, smoking and heavy alcohol use, drugs may be an important risk factor for acute pancreatitis.

KW - acute pancreatitis

KW - risk factors

KW - case-control study

U2 - 10.1007/s00228-002-0471-4

DO - 10.1007/s00228-002-0471-4

M3 - Article

VL - 58

SP - 275

EP - 283

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 1432-1041

IS - 4

ER -