A tailored biocompatible neural interface for long term monitoring in neural networks

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

Abstract

Neural interface electrodes that can record from neurons in the brain for long periods of time will be of great importance to unravel how the brain accomplishes its functions. However, current electrodes usually cause significant glia reactions and loss of neurons within the adjacent brain parenchyma. To address this challenge, a novel, polymer-based neural probe, with protrusions tailored to the target tissue, was developed to investigate which probe properties affect the development of a glial scar and neuronal cell death surrounding probes. After many cycles of testing – refinements, promising recordings of neural activity were obtained in both cerebellum
and cortex cerebri (papers I-III). In paper IV, we evaluated the importance of mechanical flexibility and demonstrated that probe flexibility has a significant impact on the astroglial scar, but not on the loss of neurons nearby. Moreover, by embedding the dummy probes in a gelatin matrix that dissolves shortly following implantation, neuronal cell death surrounding chronically (6 weeks) implanted electrodes was, for the first time, abolished. In paper V, sensory processing in primary somatosensory cortex during an episode of hyperalgesia was monitored using implanted neural interfaces in order to further evaluate the probe functionality and usefulness in neurophysiological research. By tracking the development of primary and secondary hyperalgesia as well as allodynia in the sensory cortex, we demonstrate the usefulness of our new neural interface and its capability to differentially and simultaneously record neural signals in different cortical laminae in awake freely moving animals.

Detaljer

Författare
  • Per Köhler
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Nyckelord

Originalspråkengelska
KvalifikationDoktor
Tilldelande institution
Handledare/Biträdande handledare
Tilldelningsdatum2016 mar 4
Förlag
  • Neuronano Research Center (NRC)
Tryckta ISBN978-91-7619-248-1
StatusPublished - 2016
PublikationskategoriForskning

Nedladdningar

Ingen tillgänglig data

Relaterad forskningsoutput

Köhler, P., Anette Wolff, Ejserholm, F., Lars Wallman, Jens Schouenborg & Cecilia Eriksson Linsmeier, 2015, I : PLoS ONE. 10, 3, e0119340.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Ejserholm, F., Köhler, P., Granmo, M., Jens Schouenborg, Martin Bengtsson & Lars Wallman, 2014, I : Translational Engineering in Health and Medicine, IEEE Journal of. 2

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Ejserholm, F., Köhler, P., Martin Bengtsson, Henrik Jörntell, Jens Schouenborg & Lars Wallman, 2011, 2011 5th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE--Institute of Electrical and Electronics Engineers Inc., s. 376-379 4 s.

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceeding

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