A wide spectrum of fastidious and ampicillin-susceptible bacteria dominate in animal-caused wounds

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The main purpose of this study was to assess the actual occurrence of Gram-negative oxidase-positive bacteria (GNOP) in human wounds caused by animals, mostly cat and dog bites and scratches, and with signs of infection. We report a prospective series of 92 wound samples. Routine culturing was combined with a procedure optimised for fastidious GNOP. All GNOP isolates were identified by 16S rDNA sequencing to the species level. We observed a more prominent role of GNOP, including at least 30 species mostly in the families Flavobacteriaceae, Neisseriaceae and Pasteurellaceae, and less of Staphylococcus aureus and streptococci. The antibiotic susceptibility pattern was investigated, as GNOP are associated with sudden onset of serious infections, making an early decision on antibiotic treatment vital. All GNOP isolates judged to be clinically relevant displayed susceptibility to ampicillin and meropenem, but resistance to oxacillin, clindamycin and gentamicin was frequent. Our findings emphasise the need to cover GNOP as recommended in guidelines, and not only common wound pathogens, when treating an animal-caused wound.

Detaljer

Författare
  • O. Gustavsson
  • A. V. Johansson
  • H. J. Monstein
  • L. E. Nilsson
  • A. Bredberg
Enheter & grupper
Externa organisationer
  • Linköping University Hospital
  • Linköping University
  • Innlandet Hospital Trust
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området
  • Infektionsmedicin
Originalspråkengelska
Sidor (från-till)1315-1321
Antal sidor7
TidskriftEuropean Journal of Clinical Microbiology & Infectious Diseases
Volym35
Utgivningsnummer8
StatusPublished - 2016 aug
PublikationskategoriForskning
Peer review utfördJa