Abnormal Metabolism of γ-Trace Alkaline Microprotein: The Basic Defect in Hereditary Cerebral Hemorrhage with Amyloidosis

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Abstract

ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1,2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.4 This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar components of the amyloid.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Iceland
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Klinisk laboratoriemedicin
Originalspråkengelska
Sidor (från-till)1547-1549
Antal sidor3
TidskriftNew England Journal of Medicine
Volym311
Utgivningsnummer24
StatusPublished - 1984 dec 13
PublikationskategoriForskning
Peer review utfördJa