Absolute lung size and the sex difference in breathlessness in the general population

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Abstract

Background Breathlessness is associated with major adverse health outcomes and is twice as common in women as men in the general population. We evaluated whether this is related to their lower absolute lung volumes. Methods Cross-sectional analysis of the population-based Swedish CardioPulmonarybioImage Study (SCAPIS) Pilot, including static spirometry and diffusing capacity (n = 1,013; 49% women). Breathlessness was measured using the modified Medical Research Council (mMRC) scale and analyzed using ordinal logistic regression adjusting for age, pack-years of smoking, body mass index, chronic airway limitation, asthma, chronic bronchitis, depression and anxiety in all models. Results Breathlessness was twice as common in women as in men; adjusted odds ratio (OR) 2.20 (95% confidence interval, 1.32−3.66). Lower absolute lung volumes were associated with increased breathlessness prevalence in both men and women. The sex difference in breathlessness was unchanged when adjusting for lung function in %predicted, but disappeared when controlling for absolute values of total lung capacity (OR 1.12; 0.59−2.15), inspiratory capacity (OR 1.26; 0.68−2.35), forced vital capacity (OR 0.84; 0.42−1.66), forced expiratory volume in one second (OR 0.70; 0.36−1.35) or lung diffusing capacity (OR 1.07; 0.58−1.97). Conclusion In the general population, the markedly higher prevalence of breathlessness in women is related to their smaller absolute lung volumes.

Detaljer

Författare
  • Magnus Ekström
  • Josefin Sundh
  • Linus Schiöler
  • Eva Lindberg
  • Annika Rosengren
  • Göran Bergström
  • Oskar Angerås
  • Jan Hedner
  • John Brandberg
  • Björn Bake
  • Kjell Torén
Enheter & grupper
Externa organisationer
  • Örebro University
  • Uppsala universitet, Historiska institutionen
  • Sahlgrenska University Hospital
  • Göteborgs universitet
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi
Originalspråkengelska
Artikelnummere0190876
TidskriftPLoS ONE
Volym13
Utgåva nummer1
StatusPublished - 2018 jan 1
PublikationskategoriForskning
Peer review utfördJa