Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?

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Abstract

Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14).

Detaljer

Författare
  • Tilo Kölbel
  • Karin Strandberg
  • Tobias Donath
  • Ingrid Mattiasson
  • Johan Stenflo
  • Bengt Lindblad
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)135-140
TidskriftVascular and Endovascular Surgery
Volym42
Utgåva nummer2
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa