Activation and cross-reactivity pattern of a new allergen in adhesive plaster

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Bibtex

@article{ee8dfa38336f4cbe971617dad02fcac0,
title = "Activation and cross-reactivity pattern of a new allergen in adhesive plaster",
abstract = "N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions.",
author = "Ola Bergendorff and Christer Hansson",
year = "2000",
doi = "10.1034/j.1600-0536.2000.042001011.x",
language = "English",
volume = "42",
pages = "11--17",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Federation of European Neuroscience Societies and Blackwell Publishing Ltd",
number = "1",

}