Activation of the Human Contact System on Neutrophil Extracellular Traps

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs. Copyright (C) 2009 S. Karger AG, Basel

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området

Nyckelord

Originalspråkengelska
Sidor (från-till)225-230
TidskriftJournal of Innate Immunity
Volym1
Utgåva nummer3
StatusPublished - 2009
PublikationskategoriForskning
Peer review utfördJa