Adolescents living with HIV are at higher risk of death and loss to follow up from care: Analysis of cohort data from eight health facilities in Ethiopia.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
There are limited data on the treatment outcomes of adolescents living with HIV. Our objective was to compare mortality and loss to follow up (LTFU) rates between adolescent and younger age groups at enrollment in care.
This was a retrospective cohort study carried out in eight health facilities in two regions of Ethiopia. Adolescents (age 10-14 and 15-19 year) and children (age 0-9 year) enrolled in chronic HIV care between 2005 and 2013 constituted the study population. We reviewed the individual patient charts between March and June 2014 and updated the data on the status of each patient through December 2015. We used death and loss-to-follow up as primary endpoints and used the Cox-regression analysis where age, categorized as adolescent versus child, was the main predictor variable.
Of 2058 participants studied, 52.1% were adolescents. The cohort contributed 2422 person-years of observation (PYO) during the pre-ART follow-up, whereas 1531 patients put on ART contributed 5984 PYO. Of those put on ART, 209 (13.7%) LTFU and 92 (6%) deaths were reported. Adolescents in age group 15-19 yr had the highest risk of LTFU [adjusted hazard ratio, aHR (95% CI) = 3.1 2.1, 5.0 ] followed by those in age group 10-14 yr (aHR = 1.5 [0.9, 2.3]) compared with children aged 0-9 yr. Mortality hazard was significantly higher among younger adolescents (aHR = 2.8 [1.4, 5.4]) and older adolescents (aHR = 2.3 [1.1, 4.9]) compared with children.
Adolescents are at higher risk of mortality and LTFU as compared to children ages 0-9. Younger adolescents and children had similar LTFU rates. Narrow age band disaggregated analysis can serve as useful guide for tailoring interventions to the specific needs of different age groups.
|Enheter & grupper|
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Status||Published - 2019 okt 17|
|Peer review utförd||Ja|
Inger Kristensson Hallström, Boris Magnusson, Björn Lindgren, Kristofer Hansson, Hanne Kristine Hegaard, Irén Tiberg, Kajsa Landgren, Mulatu Biru Shargie, Annelie Carlsson, Linda Kvist, Maria Ekelin, Mariette Derwig, Jonas Björk, Katarina Steen Carlsson, Malin Skoog, Åsa Lefèvre, Helena Hansson, Eva-Kristina Persson, Petra Pålsson, Degu Jerene, Markus Idvall, Staffan Bergström, Björn A Johnsson, Anna-Karin Dykes, Lena-Karin Erlandsson, Marie Edwinson Månsson, Vanja Berggren, Kjeld Schmiegelow, Bo Selander, Anders Castor, Gabriella Nilsson, Eva Nordmark, Annica Sjöström-Strand, Jenny Gårdling, Ragnhild Måstrup, Pia Lundqvist, Charlotte Castor, Bengt Sivberg, Angela Afua Quaye & Magnus C Persson
Swedish Council for Working Life and Social Research (Forte), Fanny Ekdahls Stiftelse, Crafoordska stiftelsen, Ekhagastiftelsen, Barncancerfonden, Länsstyrelsen i Östergötlands län, Diabetesfonden - Stiftelsen Svenska Diabetesförbundets Forskningsfond, Region Skåne, Swedish Research Council
2013/01/01 → …