Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

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Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk. / Brand, Judith S.; van der Schouw, Yvonne T.; Onland-Moret, N. Charlotte; Sharp, Stephen J.; Ong, Ken K.; Khaw, Kay-Tee; Ardanaz, Eva; Amiano, Pilar; Boeing, Heiner; Chirlaque, Maria-Dolores; Clavel-Chapelon, Francoise; Crowe, Francesca L.; de Lauzon-Guillain, Blandine; Duell, Eric J.; Fagherazzi, Guy; Franks, Paul; Grioni, Sara; Groop, Leif; Kaaks, Rudolf; Key, Timothy J.; Nilsson, Peter; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Quiros, J. Ramon; Rolandsson, Olov; Sacerdote, Carlotta; Sanchez, Maria-Jose; Slimani, Nadia; Teucher, Birgit; Tjonneland, Anne; Tumino, Rosario; van der A, Daphne L.; Feskens, Edith J. M.; Langenberg, Claudia; Forouhi, Nita G.; Riboli, Elio; Wareham, Nicholas J.

I: Diabetes Care, Vol. 36, Nr. 4, 2013, s. 1012-1019.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Brand, JS, van der Schouw, YT, Onland-Moret, NC, Sharp, SJ, Ong, KK, Khaw, K-T, Ardanaz, E, Amiano, P, Boeing, H, Chirlaque, M-D, Clavel-Chapelon, F, Crowe, FL, de Lauzon-Guillain, B, Duell, EJ, Fagherazzi, G, Franks, P, Grioni, S, Groop, L, Kaaks, R, Key, TJ, Nilsson, P, Overvad, K, Palli, D, Panico, S, Quiros, JR, Rolandsson, O, Sacerdote, C, Sanchez, M-J, Slimani, N, Teucher, B, Tjonneland, A, Tumino, R, van der A, DL, Feskens, EJM, Langenberg, C, Forouhi, NG, Riboli, E & Wareham, NJ 2013, 'Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk', Diabetes Care, vol. 36, nr. 4, s. 1012-1019. https://doi.org/10.2337/dc12-1020

APA

Brand, J. S., van der Schouw, Y. T., Onland-Moret, N. C., Sharp, S. J., Ong, K. K., Khaw, K-T., ... Wareham, N. J. (2013). Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk. Diabetes Care, 36(4), 1012-1019. https://doi.org/10.2337/dc12-1020

CBE

Brand JS, van der Schouw YT, Onland-Moret NC, Sharp SJ, Ong KK, Khaw K-T, Ardanaz E, Amiano P, Boeing H, Chirlaque M-D, Clavel-Chapelon F, Crowe FL, de Lauzon-Guillain B, Duell EJ, Fagherazzi G, Franks P, Grioni S, Groop L, Kaaks R, Key TJ, Nilsson P, Overvad K, Palli D, Panico S, Quiros JR, Rolandsson O, Sacerdote C, Sanchez M-J, Slimani N, Teucher B, Tjonneland A, Tumino R, van der A DL, Feskens EJM, Langenberg C, Forouhi NG, Riboli E, Wareham NJ. 2013. Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk. Diabetes Care. 36(4):1012-1019. https://doi.org/10.2337/dc12-1020

MLA

Vancouver

Brand JS, van der Schouw YT, Onland-Moret NC, Sharp SJ, Ong KK, Khaw K-T et al. Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk. Diabetes Care. 2013;36(4):1012-1019. https://doi.org/10.2337/dc12-1020

Author

Brand, Judith S. ; van der Schouw, Yvonne T. ; Onland-Moret, N. Charlotte ; Sharp, Stephen J. ; Ong, Ken K. ; Khaw, Kay-Tee ; Ardanaz, Eva ; Amiano, Pilar ; Boeing, Heiner ; Chirlaque, Maria-Dolores ; Clavel-Chapelon, Francoise ; Crowe, Francesca L. ; de Lauzon-Guillain, Blandine ; Duell, Eric J. ; Fagherazzi, Guy ; Franks, Paul ; Grioni, Sara ; Groop, Leif ; Kaaks, Rudolf ; Key, Timothy J. ; Nilsson, Peter ; Overvad, Kim ; Palli, Domenico ; Panico, Salvatore ; Quiros, J. Ramon ; Rolandsson, Olov ; Sacerdote, Carlotta ; Sanchez, Maria-Jose ; Slimani, Nadia ; Teucher, Birgit ; Tjonneland, Anne ; Tumino, Rosario ; van der A, Daphne L. ; Feskens, Edith J. M. ; Langenberg, Claudia ; Forouhi, Nita G. ; Riboli, Elio ; Wareham, Nicholas J. / Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk. I: Diabetes Care. 2013 ; Vol. 36, Nr. 4. s. 1012-1019.

RIS

TY - JOUR

T1 - Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

AU - Brand, Judith S.

AU - van der Schouw, Yvonne T.

AU - Onland-Moret, N. Charlotte

AU - Sharp, Stephen J.

AU - Ong, Ken K.

AU - Khaw, Kay-Tee

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Boeing, Heiner

AU - Chirlaque, Maria-Dolores

AU - Clavel-Chapelon, Francoise

AU - Crowe, Francesca L.

AU - de Lauzon-Guillain, Blandine

AU - Duell, Eric J.

AU - Fagherazzi, Guy

AU - Franks, Paul

AU - Grioni, Sara

AU - Groop, Leif

AU - Kaaks, Rudolf

AU - Key, Timothy J.

AU - Nilsson, Peter

AU - Overvad, Kim

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Quiros, J. Ramon

AU - Rolandsson, Olov

AU - Sacerdote, Carlotta

AU - Sanchez, Maria-Jose

AU - Slimani, Nadia

AU - Teucher, Birgit

AU - Tjonneland, Anne

AU - Tumino, Rosario

AU - van der A, Daphne L.

AU - Feskens, Edith J. M.

AU - Langenberg, Claudia

AU - Forouhi, Nita G.

AU - Riboli, Elio

AU - Wareham, Nicholas J.

PY - 2013

Y1 - 2013

N2 - OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013

AB - OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013

U2 - 10.2337/dc12-1020

DO - 10.2337/dc12-1020

M3 - Article

VL - 36

SP - 1012

EP - 1019

JO - Diabetes Reviews

T2 - Diabetes Reviews

JF - Diabetes Reviews

SN - 1935-5548

IS - 4

ER -