Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease

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Bibtex

@article{5953b66f1aa240759aa8fe453812079f,
title = "Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease",
abstract = "The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson’s disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent morphological alterations and aggregation of α-synuclein (α-syn), the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model. We found that the expression and accumulation of α-syn increased gradually in neurons of Meissner’s and Auerbach’s plexuses of the gastrointestinal tract with age (from 1 week to 2 years). In addition, α-syn was increasingly phosphorylated at the serine 129 residue, reflecting pathological alterations of the protein over time. Furthermore, α-syn was present in different subtypes of neurons expressing vasoactive intestinal polypeptide, neuronal nitric oxide synthase, or calretinin. The results indicated that BAC-α-Syn-GFP transgenic mice provide a unique model in which to study the relationship between ENS and PD pathogenesis.",
keywords = "Enteric system, Parkinson’s disease, Phosphorylation, Protein aggregation, α-synuclein",
author = "Zhong, {Chong Bin} and Chen, {Qian Qian} and Caroline Haikal and Wen Li and Alexander Svanbergsson and Meike Diepenbroek and Li, {Jia Yi}",
year = "2017",
doi = "10.1007/s12264-017-0179-1",
language = "English",
volume = "33",
pages = "483--492",
journal = "Neuroscience Bulletin",
issn = "1673-7067",
publisher = "Science Press",
number = "5",

}