Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.

Detaljer

Författare
  • Susan Peters
  • Valentina Gallo
  • Paolo Vineis
  • Lefkos T. Middleton
  • Lars Forsgren
  • Carlotta Sacerdote
  • Sabina Sieri
  • Andreas Kyrozis
  • María Dolores Chirlaque
  • Raul Zamora-Ros
  • Verena Katzke
  • Tilman Kühn
  • Olatz Mokoroa
  • Giovanna Masala
  • Eva Ardanaz
  • Salvatore Panico
  • Manuela M. Bergmann
  • Timothy J. Key
  • Elisabete Weiderpass
  • Pietro Ferrari
  • Roel Vermeulen
Enheter & grupper
Externa organisationer
  • Utrecht University
  • University Medical Center Utrecht
  • Queen Mary University
  • Imperial College London
  • Umeå University
  • Citta' della Salute e della Scienza Hospital-University of Turin
  • Istituto Nazionale dei Tumori
  • Hellenic Health Foundation, Athens
  • National and Kapodistrian University of Athens
  • Murcia Regional Health Council
  • CIBER Epidemiology and Public Health (CIBERESP)
  • University of Murcia
  • Bellvitge University Hospital-IDIBELL
  • Skåne University Hospital
  • German Cancer Research Centre
  • Instituto BIO-Donostia
  • Cancer Research and Prevention Institute
  • Health Research Institute of Navarra (IDISNA)
  • University of Naples Federico II
  • German Institute of Human Nutrition
  • University of Oxford
  • International Agency for Research on Cancer, World Health Organization
  • Navarre Public Health Institute (ISPN)
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
  • Neurologi

Nyckelord

Originalspråkengelska
TidskriftMovement Disorders
StatusE-pub ahead of print - 2020 dec 1
PublikationskategoriForskning
Peer review utfördJa