Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor

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Bibtex

@article{de31280eec3b44aba96de05eef060643,
title = "Allergic contact dermatitis caused by isobornyl acrylate in Freestyle{\circledR} Libre, a newly introduced glucose sensor",
abstract = "Background: Glucose sensors, such as FreeStyle{\circledR} Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle{\circledR} Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle{\circledR} Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the glucose sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC-MS) of the sensors was performed. Results: All patients reacted to the adhesive part of the sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC-MS showed the presence of isobornyl acrylate in the sensors. Conclusions: Cases of allergic contact dermatitis caused by FreeStyle{\circledR} Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross-reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.",
keywords = "acrylates, adhesive, allergic contact dermatitis, CAS no. 5888-33-5, diabetes mellitus, FreeStyle{\circledR} Libre, gas chromatography, glucose sensor, isobornyl acrylate, mass spectrometry, medical device, sesquiterpene lactone mix",
author = "Anne Herman and Olivier Aerts and Marie Baeck and Magnus Bruze and {De Block}, Christophe and An Goossens and Nils Hamnerius and Sara Huygens and Dominique Maiter and Dominique Tennstedt and Bernard Vandeleene and Martin Mowitz",
year = "2017",
month = "12",
day = "1",
doi = "10.1111/cod.12866",
language = "English",
volume = "77",
pages = "367--373",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Federation of European Neuroscience Societies and Blackwell Publishing Ltd",
number = "6",

}