Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor. / Herman, Anne; Aerts, Olivier; Baeck, Marie; Bruze, Magnus; De Block, Christophe; Goossens, An; Hamnerius, Nils; Huygens, Sara; Maiter, Dominique; Tennstedt, Dominique; Vandeleene, Bernard; Mowitz, Martin.

I: Contact Dermatitis, Vol. 77, Nr. 6, 01.12.2017, s. 367-373.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Herman, A, Aerts, O, Baeck, M, Bruze, M, De Block, C, Goossens, A, Hamnerius, N, Huygens, S, Maiter, D, Tennstedt, D, Vandeleene, B & Mowitz, M 2017, 'Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor', Contact Dermatitis, vol. 77, nr. 6, s. 367-373. https://doi.org/10.1111/cod.12866

APA

CBE

MLA

Vancouver

Author

Herman, Anne ; Aerts, Olivier ; Baeck, Marie ; Bruze, Magnus ; De Block, Christophe ; Goossens, An ; Hamnerius, Nils ; Huygens, Sara ; Maiter, Dominique ; Tennstedt, Dominique ; Vandeleene, Bernard ; Mowitz, Martin. / Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor. I: Contact Dermatitis. 2017 ; Vol. 77, Nr. 6. s. 367-373.

RIS

TY - JOUR

T1 - Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor

AU - Herman, Anne

AU - Aerts, Olivier

AU - Baeck, Marie

AU - Bruze, Magnus

AU - De Block, Christophe

AU - Goossens, An

AU - Hamnerius, Nils

AU - Huygens, Sara

AU - Maiter, Dominique

AU - Tennstedt, Dominique

AU - Vandeleene, Bernard

AU - Mowitz, Martin

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the glucose sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC-MS) of the sensors was performed. Results: All patients reacted to the adhesive part of the sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC-MS showed the presence of isobornyl acrylate in the sensors. Conclusions: Cases of allergic contact dermatitis caused by FreeStyle® Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross-reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.

AB - Background: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the glucose sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC-MS) of the sensors was performed. Results: All patients reacted to the adhesive part of the sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC-MS showed the presence of isobornyl acrylate in the sensors. Conclusions: Cases of allergic contact dermatitis caused by FreeStyle® Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross-reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.

KW - acrylates

KW - adhesive

KW - allergic contact dermatitis

KW - CAS no. 5888-33-5

KW - diabetes mellitus

KW - FreeStyle® Libre

KW - gas chromatography

KW - glucose sensor

KW - isobornyl acrylate

KW - mass spectrometry

KW - medical device

KW - sesquiterpene lactone mix

U2 - 10.1111/cod.12866

DO - 10.1111/cod.12866

M3 - Article

VL - 77

SP - 367

EP - 373

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 6

ER -