Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.

Detaljer

Författare
  • Alessandro Tozzi
  • Antonio de Iure
  • Vincenza Bagetta
  • Michela Tantucci
  • Valentina Durante
  • Ana Quiroga-Varela
  • Cinzia Costa
  • Massimiliano Di Filippo
  • Veronica Ghiglieri
  • Emanuele Claudio Latagliata
  • Michal Wegrzynowicz
  • Mickael Decressac
  • Carmela Giampà
  • Jeffrey W Dalley
  • Jing Xia
  • Fabrizio Gardoni
  • Manuela Mellone
  • Omar Mukhtar El-Agnaf
  • Mustafa Taleb Ardah
  • Stefano Puglisi-Allegra
  • Maria Grazia Spillantini
  • Barbara Picconi
  • Paolo Calabresi
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
Originalspråkengelska
TidskriftBiological Psychiatry
Tidigt onlinedatum2015 aug 20
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa