Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study.

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Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study. / Stepien, Magdalena; Duarte-Salles, Talita; Fedirko, Veronika; Floegel, Anne; Barupal, Dinesh Kumar; Rinaldi, Sabina; Achaintre, David; Assi, Nada; Tjønneland, Anne; Overvad, Kim; Bastide, Nadia; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Kühn, Tilman; Kaaks, Rudolf; Aleksandrova, Krasimira; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; Lagiou, Pagona; Saieva, Calogero; Agnoli, Claudia; Panico, Salvatore; Tumino, Rosario; Naccarati, Alessio; Bueno-de-Mesquita, H B As; Peeters, Petra H; Weiderpass, Elisabete; Quirós, J Ramón; Agudo, Antonio; Sánchez, María-José; Dorronsoro, Miren; Gavrila, Diana; Barricarte, Aurelio; Ohlsson, Bodil; Sjöberg, Klas; Werner, Mårten; Sund, Malin; Wareham, Nick; Khaw, Kay-Tee; Travis, Ruth C; Schmidt, Julie A; Gunter, Marc; Cross, Amanda; Vineis, Paolo; Romieu, Isabelle; Scalbert, Augustin; Jenab, Mazda.

I: International Journal of Cancer, Vol. 138, Nr. 2, 2016, s. 348-360.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Stepien, M, Duarte-Salles, T, Fedirko, V, Floegel, A, Barupal, DK, Rinaldi, S, Achaintre, D, Assi, N, Tjønneland, A, Overvad, K, Bastide, N, Boutron-Ruault, M-C, Severi, G, Kühn, T, Kaaks, R, Aleksandrova, K, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Saieva, C, Agnoli, C, Panico, S, Tumino, R, Naccarati, A, Bueno-de-Mesquita, HBA, Peeters, PH, Weiderpass, E, Quirós, JR, Agudo, A, Sánchez, M-J, Dorronsoro, M, Gavrila, D, Barricarte, A, Ohlsson, B, Sjöberg, K, Werner, M, Sund, M, Wareham, N, Khaw, K-T, Travis, RC, Schmidt, JA, Gunter, M, Cross, A, Vineis, P, Romieu, I, Scalbert, A & Jenab, M 2016, 'Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study.', International Journal of Cancer, vol. 138, nr. 2, s. 348-360. https://doi.org/10.1002/ijc.29718

APA

Stepien, M., Duarte-Salles, T., Fedirko, V., Floegel, A., Barupal, D. K., Rinaldi, S., Achaintre, D., Assi, N., Tjønneland, A., Overvad, K., Bastide, N., Boutron-Ruault, M-C., Severi, G., Kühn, T., Kaaks, R., Aleksandrova, K., Boeing, H., Trichopoulou, A., Bamia, C., ... Jenab, M. (2016). Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study. International Journal of Cancer, 138(2), 348-360. https://doi.org/10.1002/ijc.29718

CBE

Stepien M, Duarte-Salles T, Fedirko V, Floegel A, Barupal DK, Rinaldi S, Achaintre D, Assi N, Tjønneland A, Overvad K, Bastide N, Boutron-Ruault M-C, Severi G, Kühn T, Kaaks R, Aleksandrova K, Boeing H, Trichopoulou A, Bamia C, Lagiou P, Saieva C, Agnoli C, Panico S, Tumino R, Naccarati A, Bueno-de-Mesquita HBA, Peeters PH, Weiderpass E, Quirós JR, Agudo A, Sánchez M-J, Dorronsoro M, Gavrila D, Barricarte A, Ohlsson B, Sjöberg K, Werner M, Sund M, Wareham N, Khaw K-T, Travis RC, Schmidt JA, Gunter M, Cross A, Vineis P, Romieu I, Scalbert A, Jenab M. 2016. Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study. International Journal of Cancer. 138(2):348-360. https://doi.org/10.1002/ijc.29718

MLA

Vancouver

Author

Stepien, Magdalena ; Duarte-Salles, Talita ; Fedirko, Veronika ; Floegel, Anne ; Barupal, Dinesh Kumar ; Rinaldi, Sabina ; Achaintre, David ; Assi, Nada ; Tjønneland, Anne ; Overvad, Kim ; Bastide, Nadia ; Boutron-Ruault, Marie-Christine ; Severi, Gianluca ; Kühn, Tilman ; Kaaks, Rudolf ; Aleksandrova, Krasimira ; Boeing, Heiner ; Trichopoulou, Antonia ; Bamia, Christina ; Lagiou, Pagona ; Saieva, Calogero ; Agnoli, Claudia ; Panico, Salvatore ; Tumino, Rosario ; Naccarati, Alessio ; Bueno-de-Mesquita, H B As ; Peeters, Petra H ; Weiderpass, Elisabete ; Quirós, J Ramón ; Agudo, Antonio ; Sánchez, María-José ; Dorronsoro, Miren ; Gavrila, Diana ; Barricarte, Aurelio ; Ohlsson, Bodil ; Sjöberg, Klas ; Werner, Mårten ; Sund, Malin ; Wareham, Nick ; Khaw, Kay-Tee ; Travis, Ruth C ; Schmidt, Julie A ; Gunter, Marc ; Cross, Amanda ; Vineis, Paolo ; Romieu, Isabelle ; Scalbert, Augustin ; Jenab, Mazda. / Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study. I: International Journal of Cancer. 2016 ; Vol. 138, Nr. 2. s. 348-360.

RIS

TY - JOUR

T1 - Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study.

AU - Stepien, Magdalena

AU - Duarte-Salles, Talita

AU - Fedirko, Veronika

AU - Floegel, Anne

AU - Barupal, Dinesh Kumar

AU - Rinaldi, Sabina

AU - Achaintre, David

AU - Assi, Nada

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Bastide, Nadia

AU - Boutron-Ruault, Marie-Christine

AU - Severi, Gianluca

AU - Kühn, Tilman

AU - Kaaks, Rudolf

AU - Aleksandrova, Krasimira

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Lagiou, Pagona

AU - Saieva, Calogero

AU - Agnoli, Claudia

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Naccarati, Alessio

AU - Bueno-de-Mesquita, H B As

AU - Peeters, Petra H

AU - Weiderpass, Elisabete

AU - Quirós, J Ramón

AU - Agudo, Antonio

AU - Sánchez, María-José

AU - Dorronsoro, Miren

AU - Gavrila, Diana

AU - Barricarte, Aurelio

AU - Ohlsson, Bodil

AU - Sjöberg, Klas

AU - Werner, Mårten

AU - Sund, Malin

AU - Wareham, Nick

AU - Khaw, Kay-Tee

AU - Travis, Ruth C

AU - Schmidt, Julie A

AU - Gunter, Marc

AU - Cross, Amanda

AU - Vineis, Paolo

AU - Romieu, Isabelle

AU - Scalbert, Augustin

AU - Jenab, Mazda

PY - 2016

Y1 - 2016

N2 - Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer's ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development.

AB - Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer's ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development.

U2 - 10.1002/ijc.29718

DO - 10.1002/ijc.29718

M3 - Article

C2 - 26238458

VL - 138

SP - 348

EP - 360

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 2

ER -