Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.

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Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study. / Li, Huiqi; Åkerman, Gabriella; Lidén, Carola; Alhamdow, Ayman; Wojdacz, Tomasz K; Broberg Palmgren, Karin; Albin, Maria.

I: Environmental and Molecular Mutagenesis, Vol. 57, Nr. 2, 2016, s. 159-167.

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Li, Huiqi ; Åkerman, Gabriella ; Lidén, Carola ; Alhamdow, Ayman ; Wojdacz, Tomasz K ; Broberg Palmgren, Karin ; Albin, Maria. / Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study. I: Environmental and Molecular Mutagenesis. 2016 ; Vol. 57, Nr. 2. s. 159-167.

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TY - JOUR

T1 - Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.

AU - Li, Huiqi

AU - Åkerman, Gabriella

AU - Lidén, Carola

AU - Alhamdow, Ayman

AU - Wojdacz, Tomasz K

AU - Broberg Palmgren, Karin

AU - Albin, Maria

PY - 2016

Y1 - 2016

N2 - Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019) compared with non-hairdressers. Shorter telomeres were found in hairdressers up to 32 years old performing hair waving more than once per week as compared with hairdressers in the same age group performing hair waving less often (β = -0.12, P = 0.037). Hair waving was associated with less frequent CDKN2A methylation (odds ratio, OR = 0.19, P = 0.033). Shorter telomeres in hairdressers may indicate a genotoxic effect. Performing hair waving was associated with short telomere length, although the effect was only observed in young hairdressers. No clear patterns were discerned with regard to DNA methylation of bladder cancer-related genes. The observed changes of methylation were not all in the expected direction and warrant further investigation. Environ. Mol. Mutagen., 2015. © 2015 Wiley Periodicals, Inc.

AB - Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019) compared with non-hairdressers. Shorter telomeres were found in hairdressers up to 32 years old performing hair waving more than once per week as compared with hairdressers in the same age group performing hair waving less often (β = -0.12, P = 0.037). Hair waving was associated with less frequent CDKN2A methylation (odds ratio, OR = 0.19, P = 0.033). Shorter telomeres in hairdressers may indicate a genotoxic effect. Performing hair waving was associated with short telomere length, although the effect was only observed in young hairdressers. No clear patterns were discerned with regard to DNA methylation of bladder cancer-related genes. The observed changes of methylation were not all in the expected direction and warrant further investigation. Environ. Mol. Mutagen., 2015. © 2015 Wiley Periodicals, Inc.

U2 - 10.1002/em.21991

DO - 10.1002/em.21991

M3 - Article

VL - 57

SP - 159

EP - 167

JO - Environmental and Molecular Mutagenesis

T2 - Environmental and Molecular Mutagenesis

JF - Environmental and Molecular Mutagenesis

SN - 1098-2280

IS - 2

ER -