Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3. / Perez-Alcazar, Marta; Daborg, Jonny; Stokowska, Anna; Wasling, Pontus; Björefeldt, Andreas; Kalm, Marie; Zetterberg, Henrik; Carlström, Karl; Blomgren, Klas; Ekdahl Clementson, Christine; Hanse, Eric; Pekna, Marcela.

I: Experimental Neurology, Vol. 253, 2014, s. 154-164.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Perez-Alcazar, M, Daborg, J, Stokowska, A, Wasling, P, Björefeldt, A, Kalm, M, Zetterberg, H, Carlström, K, Blomgren, K, Ekdahl Clementson, C, Hanse, E & Pekna, M 2014, 'Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.', Experimental Neurology, vol. 253, s. 154-164. https://doi.org/10.1016/j.expneurol.2013.12.013

APA

Perez-Alcazar, M., Daborg, J., Stokowska, A., Wasling, P., Björefeldt, A., Kalm, M., Zetterberg, H., Carlström, K., Blomgren, K., Ekdahl Clementson, C., Hanse, E., & Pekna, M. (2014). Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3. Experimental Neurology, 253, 154-164. https://doi.org/10.1016/j.expneurol.2013.12.013

CBE

Perez-Alcazar M, Daborg J, Stokowska A, Wasling P, Björefeldt A, Kalm M, Zetterberg H, Carlström K, Blomgren K, Ekdahl Clementson C, Hanse E, Pekna M. 2014. Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3. Experimental Neurology. 253:154-164. https://doi.org/10.1016/j.expneurol.2013.12.013

MLA

Vancouver

Author

Perez-Alcazar, Marta ; Daborg, Jonny ; Stokowska, Anna ; Wasling, Pontus ; Björefeldt, Andreas ; Kalm, Marie ; Zetterberg, Henrik ; Carlström, Karl ; Blomgren, Klas ; Ekdahl Clementson, Christine ; Hanse, Eric ; Pekna, Marcela. / Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3. I: Experimental Neurology. 2014 ; Vol. 253. s. 154-164.

RIS

TY - JOUR

T1 - Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.

AU - Perez-Alcazar, Marta

AU - Daborg, Jonny

AU - Stokowska, Anna

AU - Wasling, Pontus

AU - Björefeldt, Andreas

AU - Kalm, Marie

AU - Zetterberg, Henrik

AU - Carlström, Karl

AU - Blomgren, Klas

AU - Ekdahl Clementson, Christine

AU - Hanse, Eric

AU - Pekna, Marcela

PY - 2014

Y1 - 2014

N2 - Previous work implicated the complement system in adult neurogenesis as well as elimination of synapses in the developing and injured CNS. In the present study, we used mice lacking the third complement component (C3) to elucidate the role the complement system plays in hippocampus-dependent learning and synaptic function. We found that the constitutive absence of C3 is associated with enhanced place and reversal learning in adult mice. Our findings of lower release probability at CA3-CA1 glutamatergic synapses in combination with unaltered overall efficacy of these synapses in C3 deficient mice implicate C3 as a negative regulator of the number of functional glutamatergic synapses in the hippocampus. The C3 deficient mice showed no signs of spontaneous epileptiform activity in the hippocampus. We conclude that C3 plays a role in the regulation of the number and function of glutamatergic synapses in the hippocampus and exerts negative effects on hippocampus-dependent cognitive performance.

AB - Previous work implicated the complement system in adult neurogenesis as well as elimination of synapses in the developing and injured CNS. In the present study, we used mice lacking the third complement component (C3) to elucidate the role the complement system plays in hippocampus-dependent learning and synaptic function. We found that the constitutive absence of C3 is associated with enhanced place and reversal learning in adult mice. Our findings of lower release probability at CA3-CA1 glutamatergic synapses in combination with unaltered overall efficacy of these synapses in C3 deficient mice implicate C3 as a negative regulator of the number of functional glutamatergic synapses in the hippocampus. The C3 deficient mice showed no signs of spontaneous epileptiform activity in the hippocampus. We conclude that C3 plays a role in the regulation of the number and function of glutamatergic synapses in the hippocampus and exerts negative effects on hippocampus-dependent cognitive performance.

U2 - 10.1016/j.expneurol.2013.12.013

DO - 10.1016/j.expneurol.2013.12.013

M3 - Article

C2 - 24378428

VL - 253

SP - 154

EP - 164

JO - Neurodegeneration

JF - Neurodegeneration

SN - 0014-4886

ER -