γ-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Extracellular levels of striatal γ-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric period. The results demonstrate that events associated with the onset of isoelectricity during hypoglycemia trigger an increase in extracellular concentrations of GABA and taurine. The discrepancy in time-course of these changes may reflect differences in compartmentation, function and metabolism of the two amino acids.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Karolinska Institute
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Fysiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)231-235
Antal sidor5
TidskriftNeuroscience Letters
Volym62
Utgåva nummer2
StatusPublished - 1985 dec 4
PublikationskategoriForskning
Peer review utfördJa