Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening

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Abstract

Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug/inhibitor mixture (in the particles) must form a single phase. The drug/inhibitor mixture can be characterized by the interaction parameter chi using the Bragg-Williams theory, in which single phase mixtures are obtained for chi < 2. The chi parameter can be calculated from the (crystalline) solubility of the drug in the inhibitor, provided the inhibitor is a liquid, and the melting entropy and temperature of the drug.

Detaljer

Författare
  • L Lindfors
  • P Skantze
  • U Skantze
  • M Rasmusson
  • A Zackrisson
  • Ulf Olsson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Fysikalisk kemi
Originalspråkengelska
Sidor (från-till)906-910
TidskriftLangmuir
Volym22
Utgivningsnummer3
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördJa