β-amyloid peptides inhibit acetylcholine release from cholinergic presynaptic nerve endings isolated from an electric ray

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Bibtex

@article{8b2b02ad4b1044b284e38f9678f49c7b,
title = "β-amyloid peptides inhibit acetylcholine release from cholinergic presynaptic nerve endings isolated from an electric ray",
abstract = "We investigated the effects of β-amyloid (Aβ) peptides on cholinergic synaptosomes isolated from the electric organ of the Japanese marine ray Narke japonica. Fresh and pre-incubated solutions of Aβ(1-42) inhibited acetylcholine (ACh) release from the synaptosomes evoked by high [K+] depolarization when incubated with synaptosomes for 10 min before the depolarizing stimulus. A freshly prepared solution of Aβ(1-40) did not inhibit the evoked ACh release, but prolonged pre-incubation of Aβ(1-40) solution caused the inhibition. Aβ(1-15) neither in fresh nor pre-incubated solution inhibited. These results have demonstrated that Aβ peptides can acutely inhibit the depolarization-evoked release of ACh by acting directly on cholinergic presynaptic nerve endings. The electrophoresis analysis showed a strong correlation between Aβ aggregation and its inhibition for ACh release.",
keywords = "β-Amyloid, aggregation, cholinergic neurons, electric organ, high [K] depolarization, nerve terminals, synaptosomes",
author = "Yasushi Satoh and Yutaka Hirakura and Sotaro Shibayama and Naohide Hirashima and Toshiharu Suzuki and Yutaka Kirino",
year = "2001",
month = apr,
day = "20",
doi = "10.1016/S0304-3940(01)01665-2",
language = "English",
volume = "302",
pages = "97--100",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier",
number = "2-3",

}