Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project

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Amyloid PET and cognitive decline in cognitively normal individuals : the SCIENCe project. / Timmers, Tessa; Ossenkoppele, Rik; Verfaillie, Sander C.J.; van der Weijden, Chris W.J.; Slot, Rosalinde E.R.; Wesselman, Linda M.P.; Windhorst, Albert D.; Wolters, Emma E.; Yaqub, Maqsood; Prins, Niels D.; Lammertsma, Adriaan A.; Scheltens, Philip; van der Flier, Wiesje M.; van Berckel, Bart N.M.

I: Neurobiology of Aging, Vol. 79, 2019, s. 50-58.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Timmers, T, Ossenkoppele, R, Verfaillie, SCJ, van der Weijden, CWJ, Slot, RER, Wesselman, LMP, Windhorst, AD, Wolters, EE, Yaqub, M, Prins, ND, Lammertsma, AA, Scheltens, P, van der Flier, WM & van Berckel, BNM 2019, 'Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project', Neurobiology of Aging, vol. 79, s. 50-58. https://doi.org/10.1016/j.neurobiolaging.2019.02.020

APA

Timmers, T., Ossenkoppele, R., Verfaillie, S. C. J., van der Weijden, C. W. J., Slot, R. E. R., Wesselman, L. M. P., ... van Berckel, B. N. M. (2019). Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project. Neurobiology of Aging, 79, 50-58. https://doi.org/10.1016/j.neurobiolaging.2019.02.020

CBE

Timmers T, Ossenkoppele R, Verfaillie SCJ, van der Weijden CWJ, Slot RER, Wesselman LMP, Windhorst AD, Wolters EE, Yaqub M, Prins ND, Lammertsma AA, Scheltens P, van der Flier WM, van Berckel BNM. 2019. Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project. Neurobiology of Aging. 79:50-58. https://doi.org/10.1016/j.neurobiolaging.2019.02.020

MLA

Vancouver

Author

Timmers, Tessa ; Ossenkoppele, Rik ; Verfaillie, Sander C.J. ; van der Weijden, Chris W.J. ; Slot, Rosalinde E.R. ; Wesselman, Linda M.P. ; Windhorst, Albert D. ; Wolters, Emma E. ; Yaqub, Maqsood ; Prins, Niels D. ; Lammertsma, Adriaan A. ; Scheltens, Philip ; van der Flier, Wiesje M. ; van Berckel, Bart N.M. / Amyloid PET and cognitive decline in cognitively normal individuals : the SCIENCe project. I: Neurobiology of Aging. 2019 ; Vol. 79. s. 50-58.

RIS

TY - JOUR

T1 - Amyloid PET and cognitive decline in cognitively normal individuals

T2 - Neurobiology of Aging

AU - Timmers, Tessa

AU - Ossenkoppele, Rik

AU - Verfaillie, Sander C.J.

AU - van der Weijden, Chris W.J.

AU - Slot, Rosalinde E.R.

AU - Wesselman, Linda M.P.

AU - Windhorst, Albert D.

AU - Wolters, Emma E.

AU - Yaqub, Maqsood

AU - Prins, Niels D.

AU - Lammertsma, Adriaan A.

AU - Scheltens, Philip

AU - van der Flier, Wiesje M.

AU - van Berckel, Bart N.M.

PY - 2019

Y1 - 2019

N2 - We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.

AB - We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.

KW - Amyloid-β

KW - Cognition

KW - Positron emission tomography (PET)

KW - Preclinical Alzheimer's disease

KW - Subjective cognitive decline (SCD)

U2 - 10.1016/j.neurobiolaging.2019.02.020

DO - 10.1016/j.neurobiolaging.2019.02.020

M3 - Article

VL - 79

SP - 50

EP - 58

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 1558-1497

ER -