An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves

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An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves. / Fornell, Anna; Ohlin, Mathias; Garofalo, Fabio; Nilsson, Johan; Tenje, Maria.

I: Biomicrofluidics, Vol. 11, Nr. 3, 031101, 01.05.2017.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves

AU - Fornell, Anna

AU - Ohlin, Mathias

AU - Garofalo, Fabio

AU - Nilsson, Johan

AU - Tenje, Maria

PY - 2017/5/1

Y1 - 2017/5/1

N2 - To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

AB - To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

UR - http://www.scopus.com/inward/record.url?scp=85019714138&partnerID=8YFLogxK

U2 - 10.1063/1.4984131

DO - 10.1063/1.4984131

M3 - Article

VL - 11

JO - Biomicrofluidics

JF - Biomicrofluidics

SN - 1932-1058

IS - 3

M1 - 031101

ER -