An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients

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Abstract

In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.

Detaljer

Författare
  • Hareth Nahi
  • Hans Hägglund
  • Thomas Ahlgren
  • Per Bernell
  • Mats Hardling
  • Karin Karlsson
  • Vladimir Lj Lazarevic
  • Mats Linderholm
  • Bengt Smedmyr
  • Maria Aström
  • Helene Hallböök
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Norrland University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Hematologi

Nyckelord

Originalspråkengelska
Sidor (från-till)1734-8
Antal sidor5
TidskriftHaematologica
Volym93
Utgivningsnummer11
StatusPublished - 2008 nov
PublikationskategoriForskning
Peer review utfördJa