An isocaloric nordic diet modulates rela and tnfrsf1a gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome—a sysdiet sub-study

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A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.


  • Stine M. Ulven
  • Kirsten B. Holven
  • Amanda Rundblad
  • Mari C.W. Myhrstad
  • Lena Leder
  • Ingrid Dahlman
  • Vanessa D. de Mello
  • Ursula Schwab
  • Carsten Carlberg
  • Jussi Pihlajamäki
  • Kjeld Hermansen
  • Lars O. Dragsted
  • Ingibjörg Gunnarsdottir
  • Fredrik Rosqvist
  • Janne Hukkanen
  • Karl Heinz Herzig
  • Markku J. Savolainen
  • Ulf Risérus
  • Inga Thorsdottir
  • Kaisa S. Poutanen
  • Peter Arner
  • Matti Uusitupa
  • Marjukka Kolehmainen
Enheter & grupper
Externa organisationer
  • University of Oslo
  • Oslo university hospital
  • Karolinska Institute
  • University of Eastern Finland
  • Kuopio University Hospital
  • Aarhus University Hospital
  • University of Copenhagen
  • National University Hospital of Iceland
  • Skåne University Hospital
  • Uppsala universitet
  • Oulu University Hospital
  • Poznan University of Medical Sciences
  • VTT Technical Research Centre of Finland, Helsinki
  • Oslo Metropolitan University
  • Mills AS
  • University of Oulu

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik
  • Cellbiologi


Utgåva nummer12
StatusPublished - 2019 dec 3
Peer review utfördJa