Animal Models of Parkinson’s Disease

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

Abstract

Parkinson’s disease (PD) is a heterogenous disease with a varying age of onset, symptoms, and rate of progression. This heterogeneity requires the use of a variety of animal models to study different aspects of the disease. Neurotoxin-based approaches include exposure of rodents or non-human primates to 6-OHDA, MPTP, and agrochemicals such as the pesticide rotenone, the herbicide paraquat, and the fungicide maneb. Acute exposure to neurotoxins induces motor deficits and rapid nigro-striatal dopaminergic cell death by disrupting mitochondrial function and/or increasing oxidative stress, while chronic administration of neurotoxins induces progressive models which can include alpha-synuclein (α-synuclein) aggregates. Genetic-based approaches to model Parkinson’s disease include transgenic models and viral vector-mediated models based on genes linked to monogenic Parkinson’s disease, including SNCA, LRRK2, UCH-L1, PRKN, PINK1, and and DJ-1, as well as manipulation of dopaminergic transcription factors. SNCA mutations, overexpression, and introduction of α-synuclein preformed fibrils induce toxic protein aggregates and variable nigro-striatal neurodegeneration and motor deficits, depending on the specific model. Species, genetic background of a strain, and environment affect the display of symptoms and neurodegenerative hallmarks of animal models. These models can be combined to study the interplay between genetics and environment and untangle the heterogeneity and mechanisms underlying Parkinson’s disease. In this chapter, we discuss the strengths and limitations of mouse, rat, and non-human primate models of Parkinson’s disease.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Lund University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Medicinsk genetik

Nyckelord

Originalspråkengelska
Titel på värdpublikationParkinson's Disease
Undertitel på gästpublikationPathogenesis and Clinical Aspects
RedaktörerThomas B. Stoker, Julia C. Greenland
UtgivningsortBrisbane (AU)
FörlagCodon Publications
???Chapter???5
Sidor83-106
ISBN (tryckt)978-0-9944381-6-4
StatusPublished - 2018 dec 21
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Jewett, M., Dickson, E., Brolin, K., Negrini, M., Itzia Jimenez-Ferrer & Maria Swanberg, 2018 apr 6, I : Frontiers in Neurology. 9, APR, 222.

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Jewett, M., Itzia Jimenez & Maria Swanberg, 2017 jul 1, I : Brain Sciences. 7, 7, 73.

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