Anthropometry and the risk of lung cancer in EPIC

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)2) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.

Detaljer

Författare
  • Nikmah Utami Dewi
  • Hendriek C. Boshuizen
  • Mattias Johansson
  • Paolo Vineis
  • Ellen Kampman
  • Annika Steffen
  • Anne Tjønneland
  • Jytte Halkjær
  • Kim Overvad
  • Gianluca Severi
  • Guy Fagherazzi
  • Marie Christine Boutron-Ruault
  • Rudolf Kaaks
  • Kuanrong Li
  • Heiner Boeing
  • Antonia Trichopoulou
  • Christina Bamia
  • Eleni Klinaki
  • Rosario Tumino
  • Domenico Palli
  • Amalia Mattiello
  • Giovanna Tagliabue
  • Petra H. Peeters
  • Roel Vermeulen
  • Elisabete Weiderpass
  • Inger Torhild Gram
  • José María Huerta
  • Antonio Agudo
  • María José Sánchez
  • Eva Ardanaz
  • Miren Dorronsoro
  • José Ramón Quirós
  • Mikael Johansson
  • Kjell Grankvist
  • Tim Key
  • Kay Tee Khaw
  • Nick Wareham
  • Amanda J. Cross
  • Teresa Norat
  • Elio Riboli
  • Anouar Fanidi
  • David Muller
  • H. Bas Bueno-De-Mesquita
Enheter & grupper
Externa organisationer
  • Tadulako University
  • Wageningen University
  • International Agency for Research on Cancer, World Health Organization
  • Imperial College London
  • German Institute of Human Nutrition
  • Danish Cancer Society Research Center
  • Aarhus University
  • Human Genetic Foundation (HuGeF)
  • Institut Gustave Roussy
  • German Cancer Research Centre
  • National and Kapodistrian University of Athens
  • Hellenic Health Foundation, Athens
  • Civic and M.P.Arezzo Hospital
  • Cancer Research and Prevention Institute
  • University of Naples Federico II
  • Istituto Nazionale dei Tumori
  • University Medical Center Utrecht
  • Utrecht University
  • Folkhälsan Research Centre
  • UiT The Arctic University of Norway, Tromsø
  • CIBER Epidemiology and Public Health (CIBERESP)
  • Bellvitge University Hospital-IDIBELL
  • University of Granada
  • Health Research Institute of Navarra (IDISNA)
  • Instituto BIO-Donostia
  • Public Health Directorate
  • University of Oxford
  • University of Cambridge
  • University of Malaya
  • Skåne University Hospital
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)129-139
Antal sidor11
TidskriftAmerican Journal of Epidemiology
Volym184
Utgivningsnummer2
StatusPublished - 2016 jul 15
PublikationskategoriForskning
Peer review utfördJa