Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.

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Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy. / Schmitt, Roland; Lindahl, Gunnar; Karpman, Diana.

I: Pediatric Nephrology, Vol. 25, Nr. 9, 172, 2010, s. 1830-1830.

Forskningsoutput: TidskriftsbidragPublicerat konferensabstract

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T1 - Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.

AU - Schmitt, Roland

AU - Lindahl, Gunnar

AU - Karpman, Diana

PY - 2010

Y1 - 2010

N2 - BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.

AB - BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.

U2 - 10.1007/s00467-010-1577-z

DO - 10.1007/s00467-010-1577-z

M3 - Published meeting abstract

VL - 25

SP - 1830

EP - 1830

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 1432-198X

IS - 9

M1 - 172

T2 - 15th Congress of the International Pediatric Nephrology Association

Y2 - 29 August 2010 through 2 September 2010

ER -