Antiproliferative effects of peracetylated naphthoxylosides.

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Antiproliferative effects of peracetylated naphthoxylosides. / Aili, Ulrika; Jacobsson, Mårten; Johnsson, Richard; Mani, Katrin; Ellervik, Ulf.

I: Bioorganic & Medicinal Chemistry Letters, Vol. 19, 2009, s. 1763-1766.

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Aili, Ulrika ; Jacobsson, Mårten ; Johnsson, Richard ; Mani, Katrin ; Ellervik, Ulf. / Antiproliferative effects of peracetylated naphthoxylosides. I: Bioorganic & Medicinal Chemistry Letters. 2009 ; Vol. 19. s. 1763-1766.

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TY - JOUR

T1 - Antiproliferative effects of peracetylated naphthoxylosides.

AU - Aili, Ulrika

AU - Jacobsson, Mårten

AU - Johnsson, Richard

AU - Mani, Katrin

AU - Ellervik, Ulf

PY - 2009

Y1 - 2009

N2 - The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.

AB - The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.

U2 - 10.1016/j.bmcl.2009.01.065

DO - 10.1016/j.bmcl.2009.01.065

M3 - Article

VL - 19

SP - 1763

EP - 1766

JO - Bioorganic and Medicinal Chemistry Letters

T2 - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 1090-2120

ER -