Anti-trypanosomal alkaloids from Xymalos monospora

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.

Detaljer

Författare
  • Dieudonne Ngarnga
  • Pierre Tane
  • Donna Rattendi
  • Cyrus Bacchi
  • Christopher C. Okunji
  • Maurice M. Iwu
  • Brian M. Schuster
  • Olov Sterner
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Organisk kemi

Nyckelord

Originalspråkengelska
Sidor (från-till)619-622
TidskriftNatural Product Communications
Volym1
Utgåva nummer8
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördJa