APC-PCI complex levels for screening of AAA in patients with peripheral atherosclerosis.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11 %, a sensitivity of 97 % and a negative predictive value of 96 % for an AAA diagnosis. APC-PCI levels were higher in patients with AAA, and showed high sensitivity but low specificity for the diagnosis and can therefore not be considered as a screening tool in PAD patients. An AAA prevalence of 13 % in patients with PAD indicates a need for AAA screening within this population.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Originalspråkengelska
Sidor (från-till)495-500
TidskriftJournal of Thrombosis and Thrombolysis
Volym36
Utgivningsnummer4
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Moncef Zarrouk, 2015, Unit for Clinical Vascular Disease Research. 79 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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